Gastroplus 10.2
GastroPlus 10.2: Physiologically Based PBPK/PBBM Modeling Software GastroPlus 10.2 (GPX.2) is Simulations Plus’ latest major release of the physiologically based pharmacokinetic (PBPK) modeling software. Described as “the largest upgrade ever,” this version introduces the ACATPlus GI model, AI-powered tools, and significant automation enhancements . Key New Features in Version 10.2 ACATPlus Advanced GI Model Expanded Compartments: Extended from classic ACAT model to 13 compartments with new colon sub-divisions (ascending, transverse, descending, sigmoid, rectum) and detailed tissue layers (mucus, mucosa, submucosa, muscle) Microbiome Metabolism: Simulates compound transformation by gut microbiota Local Tissue Concentrations: Predicts drug levels in intestinal tissues, critical for locally acting drugs New Dosing Routes Intramuscular (IM) & Subcutaneous (SubQ) Models: Simulate long-acting injectable formulations; accounts for particle size,...