Tags :immunopeptidomics

Spectronaut 21.1: DIA Proteomics & Multiomics Platform Spectronaut 21.1 is the latest version of Biognosys’ flagship software for data-independent acquisition (DIA) proteomics, officially launched in June 2025 . This release delivers significant advancements in four key areas: next‑generation directDIA, AI‑driven PTM analysis, immunopeptidomics control, and large‑scale cohort performance optimization . Key New Features in Version 21 Enhanced directDIA & Identification Depth Spectronaut 21 delivers substantial improvements for library‑free DIA discovery workflows, powered by next‑generation directDIA with advanced machine and deep learning : ~10% more protein groups across 65 benchmark proteomics datasets, and ~11% more peptides across 27 immunopeptidomics datasets AI/ML scoring enhancements for both tryptic and unspecific peptides Automated sub‑sample runs to boost efficiency for large‑scale cohort analyses Up to...

pectronaut 21.0 is the Biognosys’ gold-standard software for data-independent acquisition (DIA) proteomics analysis. Trusted by researchers at leading institutions worldwide including Yale University, Max Planck Institute, and Bruker Corporation, it delivers unparalleled throughput and precision for protein identification and quantification across discovery, translational, and clinical research applications. What’s New in Spectronaut 21.0 Advanced ML Scoring & AI Models ~10% more protein groups identified on average across 65 proteomics datasets ~11% more immunopeptides identified across 27 immunopeptidomics datasets Next-generation AI models accurately predict unseen post-translational modifications (PTMs) Improved AI predictions for both tryptic and unspecific peptides Improved Computational Performance Up to 30% faster merging steps when parallelizing 10% faster directDIA for immunopeptidomics (Class I and II) 15% faster directDIA for timsTOF...